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MSOME

MSOME (Motile Sperm Organelle Morphology Examination) is a process performed at the Male Fertility Center under an overall optical magnification of 6300.

This high magnification enables the team to look at sperm organelles that are invisible in the routine examinations.
MSOME can be used as a diagnostic tool for male infertility in cases of unexplained infertility or in cases of unsuccessful IVF (In vitro fertilization). ICSI enables the ruling out of unrecognized male infertility problems. MSOME enables MFC embryologists to determine in each case, whether the IMSI procedure should be used, or whether standard ICSI is sufficient.

By examining sperm morphology at high magnification (>6,600), investigators et al demonstrated over a decade ago (2002) that Real-time fine morphology of motile human sperm cells is associated with IVF-ICSI outcome.(  (Bartoov, B., Berkovitz, A., Eltes, F., Kogosovsky, A., Menezo., Barak, Y)

Thus, it is currently accepted that spermatozoa without morphologic anomalies give higher fertilization and pregnancy outcomes.During the MSOME process, highly trained professionals embryologists examine sperm. The MSOME assesses six sperm organelles: the acrosome, post-acrosomal lamina, neck, tail, mitochondria and nucleus. Among the six organelles, the sperm nucleus seems to be the most important. It is accepted that the morphological normalcy of the sperm nucleus is evaluated in terms of shape (smooth, symmetric and oval) and chromatin content. More recently, the analysis of the presence of vacuoles has gained particular prominence with respect to the outcomes of assisted reproductive technology (ART).

This examination process is used to better determine the next appropriate stage, before spermatozoa are implanted into an egg in assisted reproductive technology (ART) procedures.

The MSOME method has allowed the introduction of a modified microinjection procedure, intracytoplasmic morphologically selected sperm injection (IMSI). 
To learn more about MSOME services at MFC labs, please contact us.